Absconding with the Chaperone: Essential Cyclophilin–Gag Interaction in HIV-1 Virions

Absconding with the Chaperone: Essential Cyclophilin–Gag Interaction in HIV-1 Virions

Does CyP play a role in HIV-1 replication? CyPA, the member of the CyP family that colocalizes with Gag in College of Physicians and Surgeons 701 West 168th Street the cytoplasm, is specifically incorporated into HIV-1 virions via interaction with the Gag polyprotein Gag binding to CyPA requires a proline-rich region located in the center of the CA domain, and mutation of a single proline, P90,...

Interactions of Infectious HIV-1 Virions with Erythrocytes: Implications for HIV-1 Pathogenesis and Infectivity

The chaperone ability comparison of norma II-casein and modified d-casein upon interaction with lysozinie

Diminishing protein aggregation by chaperone is very important factor in medicine and industry. In this paper, itis induced the chaperone ability for 0-casein upon modification of its acidic residues by Woodward reagentK(WRK) and examined on lysozyme as a target protein at pH 7.2 and outlined the mechanism for chaperoneability of modified system by UV-Vis and fluorescence spectroscopy and theor...

Macrophages archive HIV-1 virions for dissemination in trans.

Viruses have evolved various strategies in order to persist within the host. To date, most information on mechanisms of HIV-1 persistence has been derived from studies with lymphocytes, but there is little information regarding mechanisms that govern HIV-1 persistence in macrophages. It has previously been demonstrated that virus assembly in macrophages occurs in cytoplasmic vesicles, which exh...

Complementation of integrase function in HIV-1 virions.

Proviral integration is essential for HIV-1 replication and represents an important potential target for antiviral drug design. Although much is known about the integration process from studies of purified integrase (IN) protein and synthetic target DNA, provirus formation in virally infected cells remains incompletely understood since reconstituted in vitro assays do not fully reproduce in viv...